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\u5316\u5b66\u7ed3\u6784<\/p>\n

\u53cc\u4eb2\u5206\u5b50<\/p>\n

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\u8868\u9762\u6d3b\u6027\u5242<\/p>\n

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H\u00b7L\u00b7B\u503c<\/p>\n

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\u6d4a\u70b9<\/p>\n

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<\/p>\n

\u6027\u8d28<\/p>\n

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\u5438\u9644\u6027<\/p>\n

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\u539f\u7406<\/p>\n

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\u5206\u7c7b<\/p>\n

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\u4eba\u4eec\u4e00\u822c\u90fd\u8ba4\u4e3a\u6309\u7167\u5b83\u7684\u5316\u5b66\u7ed3\u6784\u6765\u5206\u6bd4\u8f83\u5408\u9002\u3002\u5373\u5f53\u8868\u9762\u6d3b\u6027\u5242\u6eb6\u89e3\u4e8e\u6c34\u540e\uff0c\u6839\u636e\u662f\u5426\u751f\u6210\u79bb\u5b50\u53ca\u5176\u7535\u6027\uff0c\u5206\u4e3a\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242\u548c\u975e\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242\u3002<\/p>\n

\u6309\u6781\u6027\u57fa\u56e2\u7684\u89e3\u79bb\u6027\u8d28\u5206\u7c7b<\/p>\n

1.\u9634\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff1a\u786c\u8102\u9178\uff0c\u5341\u4e8c\u70f7\u57fa\u82ef\u78fa\u9178\u94a0<\/p>\n

2.\u9633\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff1a\u5b63\u94f5\u5316\u7269\u3002<\/p>\n

3.\u4e24\u6027\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff1a\u5375\u78f7\u8102\uff0c\u6c28\u57fa\u9178\u578b\uff0c\u751c\u83dc\u78b1\u578b\u3002<\/p>\n

4.\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff1a\u70f7\u57fa\u8461\u7cd6\u82f7\uff08APG\uff09\uff0c\u8102\u80aa\u9178\u7518\u6cb9\u916f\uff0c\u8102\u80aa\u9178\u5c71\u68a8\u5766\uff08\u53f8\u76d8\uff09\uff0c\u805a\u5c71\u68a8\u916f\uff08\u5410\u6e29\uff09\u3002<\/p>\n

<\/p>\n

\u9634\u79bb\u5b50<\/p>\n

1.\u80a5\u7682\u7c7b<\/p>\n

\u8868\u9762\u6d3b\u6027\u5242\u80a5\u7682<\/p>\n

\u7cfb\u9ad8\u7ea7\u8102\u80aa\u9178\u7684\u76d0\uff0c\u901a\u5f0f\uff1a (RCOO)nM\u3002\u8102\u80aa\u9178\u70c3R\u4e00\u822c\u4e3a11~17\u4e2a\u78b3\u7684\u957f\u94fe\uff0c\u5e38\u89c1\u6709\u786c\u8102\u9178\u3001\u6cb9\u9178\u3001\u6708\u6842\u9178\u3002\u6839\u636eM\u4ee3\u8868\u7684\u7269\u8d28\u4e0d\u540c\uff0c\u53c8\u53ef\u5206\u4e3a\u78b1\u91d1\u5c5e\u7682\u3001\u78b1\u571f\u91d1\u5c5e\u7682\u548c\u6709\u673a\u80fa\u7682\u3002\u5b83\u4eec\u5747\u6709\u826f\u597d\u7684\u4e73\u5316\u6027\u80fd\u548c\u5206\u6563\u6cb9\u7684\u80fd\u529b\u3002\u4f46\u6613\u88ab\u7834\u574f\uff0c\u78b1\u91d1\u5c5e\u7682\u8fd8\u53ef\u88ab\u9499\u3001\u9541\u76d0\u7834\u574f\uff0c\u7535\u89e3\u8d28\u4ea6\u53ef\u4f7f\u4e4b\u76d0\u6790\u3002<\/p>\n

\u78b1\u91d1\u5c5e\u7682\uff1aO\/W<\/p>\n

\u78b1\u571f\u91d1\u5c5e\u7682\uff1aW\/O<\/p>\n

\u6709\u673a\u80fa\u7682\uff1a\u4e09\u4e59\u9187\u80fa\u7682<\/p>\n

2.\u786b\u9178\u5316\u7269 RO-SO3-M<\/p>\n

\u4e3b\u8981\u662f\u786b\u9178\u5316\u6cb9\u548c\u9ad8\u7ea7\u8102\u80aa\u9187\u786b\u9178\u916f\u7c7b\u3002\u8102\u80aa\u70c3\u94feR\u572812~18\u4e2a\u78b3\u4e4b\u95f4\u3002\u786b\u9178\u5316\u6cb9\u7684\u4ee3\u8868\u662f\u786b\u9178\u5316\u84d6\u9ebb\u6cb9\uff0c\u4fd7\u79f0\u571f\u8033\u5176\u7ea2\u6cb9\u3002\u9ad8\u7ea7\u8102\u80aa\u9187\u786b\u9178\u916f\u7c7b\u6709\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\uff08SDS\u3001\u6708\u6842\u9187\u786b\u9178\u94a0\uff09\uff0c\u4e73\u5316\u6027\u5f88\u5f3a\uff0c\u4e14\u8f83\u7a33\u5b9a\uff0c\u8f83\u8010\u9178\u548c\u9499\u3001\u9541\u76d0\u3002\u5728\u836f\u5242\u5b66\u4e0a\u53ef\u4e0e\u4e00\u4e9b\u9ad8\u5206\u5b50\u9633\u79bb\u5b50\u836f\u7269\u4ea7\u751f\u6c89\u6dc0\uff0c\u5bf9\u7c98\u819c\u6709\u4e00\u5b9a\u523a\u6fc0\u6027\uff0c\u7528\u4f5c\u5916\u7528\u8f6f\u818f\u7684\u4e73\u5316\u5242\uff0c\u4e5f\u7528\u4e8e\u7247\u5242\u7b49\u56fa\u4f53\u5236\u5242\u7684\u6da6\u6e7f\u6216\u589e\u6eb6\u3002<\/p>\n

3.\u78fa\u9178\u5316\u7269 R-SO3-M<\/p>\n

\u5c5e\u4e8e\u8fd9\u7c7b\u7684\u6709\u8102\u80aa\u65cf\u78fa\u9178\u5316\u7269\u3001\u70f7\u57fa\u82b3\u57fa\u78fa\u9178\u5316\u7269\u548c\u70f7\u57fa\u8418\u78fa\u9178\u5316\u7269\u3002\u5b83\u4eec\u7684\u6c34\u6eb6\u6027\u548c\u8010\u9178\u8010\u9499\u3001\u9541\u76d0\u6027\u6bd4\u786b\u9178\u5316\u7269\u7a0d\u5dee\uff0c\u4f46\u5728\u9178\u6027\u6eb6\u6db2\u4e2d\u4e0d\u6613\u6c34\u89e3\u3002<\/p>\n

\u5e38\u7528\u54c1\u79cd\u6709\uff1a\u4e8c\u8f9b\u57fa\u7425\u73c0\u9178\u78fa\u9178\u94a0\uff08\u963f\u6d1b\u7d22-OT\uff09\uff0c\u5341\u4e8c\u70f7\u57fa\u82ef\u78fa\u9178\u94a0\uff0c\u7518\u80c6\u9178\u94a0\u3002<\/p>\n

\u9633\u79bb\u5b50<\/p>\n

\u8be5\u7c7b\u8868\u9762\u6d3b\u6027\u5242\u8d77\u4f5c\u7528\u7684\u90e8\u5206\u662f\u9633\u79bb\u5b50\uff0c\u56e0\u6b64\u79f0\u4e3a\u9633\u6027\u7682\u3002\u5176\u5206\u5b50\u7ed3\u6784\u4e3b\u8981\u90e8\u5206\u662f\u4e00\u4e2a\u4e94\u4ef7\u6c2e\u539f\u5b50\uff0c\u6240\u4ee5\u4e5f\u79f0\u4e3a\u5b63\u94f5\u5316\u5408\u7269\u3002\u5176\u7279\u70b9\u662f\u6c34\u6eb6\u6027\u5927\uff0c\u5728\u9178\u6027\u4e0e\u78b1\u6027\u6eb6\u6db2\u4e2d\u8f83\u7a33\u5b9a\uff0c\u5177\u6709\u826f\u597d\u7684\u8868\u9762\u6d3b\u6027\u4f5c\u7528\u548c\u6740\u83cc\u4f5c\u7528\u3002<\/p>\n

\u5e38\u7528\u54c1\u79cd\u6709\u82ef\u624e\u6c2f\u94f5(\u6d01\u5c14\u706d\uff09\u548c\u82ef\u624e\u6eb4\u94f5\uff08\u65b0\u6d01\u5c14\u706d\uff09\u7b49\u3002<\/p>\n

\u4e24\u6027\u79bb\u5b50<\/p>\n

\u8fd9\u7c7b\u8868\u9762\u6d3b\u6027\u5242\u7684\u5206\u5b50\u7ed3\u6784\u4e2d\u540c\u65f6\u5177\u6709\u6b63\u3001\u8d1f\u7535\u8377\u57fa\u56e2\uff0c\u5728\u4e0d\u540cpH\u503c\u4ecb\u8d28\u4e2d\u53ef\u8868\u73b0\u51fa\u9633\u79bb\u5b50\u6216\u9634\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\u7684\u6027\u8d28\u3002<\/p>\n

1.\u5375\u78f7\u8102\uff1a\u662f\u5236\u5907\u6ce8\u5c04\u7528\u4e73\u5242\u53ca\u8102\u8d28\u5fae\u7c92\u5236\u5242\u7684\u4e3b\u8981\u8f85\u6599<\/p>\n

2.\u6c28\u57fa\u9178\u578b\u548c\u751c\u83dc\u78b1\u578b\uff1a<\/p>\n

\u6c28\u57fa\u9178\u578b\uff1aR-NH+CH2CH2COO-<\/p>\n

\u751c\u83dc\u78b1\u578b\uff1aR-N+2-(CH3)2COO-<\/p>\n

\u5728\u78b1\u6027\u6c34\u6eb6\u6db2\u4e2d\u5448\u9634\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\u7684\u6027\u8d28\uff0c\u5177\u6709\u5f88\u597d\u7684\u8d77\u6ce1\u3001\u53bb\u6c61\u4f5c\u7528\uff1b\u5728\u9178\u6027\u6eb6\u6db2\u4e2d\u5219\u5448\u9633\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\u7684\u6027\u8d28\uff0c\u5177\u6709\u5f88\u5f3a\u7684\u6740\u83cc\u80fd\u529b\u3002<\/p>\n

\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242<\/p>\n

1.\u70f7\u57fa\u8461\u7cd6\u82f7<\/p>\n

\u4e00\u79cd\u65b0\u578b\u7684\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff0c\u5e38\u89c1\u7684\u6709\u6930\u6cb9\u57fa\u8461\u7cd6\u82f7\u3001\u6708\u6842\u57fa\u8461\u7cd6\u82f7\u3001\u9cb8\u8721\u786c\u8102\u57fa\u8461\u7cd6\u82f7\u7b49\u3002<\/p>\n

2.\u8102\u80aa\u9178\u7518\u6cb9\u916f\uff1a\u5355\u786c\u8102\u9178\u7518\u6cb9\u916f\uff1b<\/p>\n

HLB\u4e3a3~4\uff0c\u4e3b\u8981\u7528\u4f5cW\/O\u578b\u4e73\u5242\u8f85\u52a9\u4e73\u5316\u5242\u3002<\/p>\n

3.\u591a\u5143\u9187<\/p>\n

\u8517\u7cd6\u916f\uff1aHLB\uff085~13\uff09O\/W\u4e73\u5316\u5242\u3001\u5206\u6563\u5242<\/p>\n

\u8102\u80aa\u9178\u5c71\u68a8\u5766\uff08Span\uff09 \uff1aW\/O\u4e73\u5316\u5242<\/p>\n

\u805a\u5c71\u68a8\u916f\uff08Tween\uff09 \uff1aO\/W\u4e73\u5316\u5242<\/p>\n

3.\u805a\u6c27\u4e59\u70ef\u578b\uff1aMyrij\uff08\u5356\u6cfd\u7c7b\uff0c\u957f\u94fe\u8102\u80aa\u9178\u916f\uff09\uff1bBrij \uff08\u8102\u80aa\u9187\u916f\uff09<\/p>\n

4.\u805a\u6c27\u4e59\u70ef-\u805a\u6c27\u4e19\u70ef\u5171\u805a\u7269\uff1aPoloxamer<\/p>\n

\u80fd\u8010\u53d7\u70ed\u538b\u706d\u83cc\u548c\u4f4e\u6e29\u51b0\u51bb\uff0c\u9759\u8109\u4e73\u5242\u7684\u4e73\u5316\u5242<\/p>\n

\u5e94\u7528<\/p>\n

\u8868\u9762\u6d3b\u6027\u5242\u7531\u4e8e\u5177\u6709\u6da6\u6e7f\u6216\u6297\u7c98\u3001\u4e73\u5316\u6216\u7834\u4e73\u3001\u8d77\u6ce1\u6216\u6d88\u6ce1\u4ee5\u53ca\u589e\u6eb6\u3001\u5206\u6563\u3001\u6d17\u6da4\u3001\u9632\u8150\u3001\u6297\u9759\u7535\u7b49\u4e00\u7cfb\u5217\u7269\u7406\u5316\u5b66\u4f5c\u7528\u53ca\u76f8\u5e94\u7684\u5b9e\u9645\u5e94\u7528\uff0c\u6210\u4e3a\u4e00\u7c7b\u7075\u6d3b\u591a\u6837\u3001\u7528\u9014\u5e7f\u6cdb\u7684\u7cbe\u7ec6\u5316\u5de5\u4ea7\u54c1\u3002\u8868\u9762\u6d3b\u6027\u5242\u9664\u4e86\u5728\u65e5\u5e38\u751f\u6d3b\u4e2d\u4f5c\u4e3a\u6d17\u6da4\u5242\uff0c\u5176\u4ed6\u5e94\u7528\u51e0\u4e4e\u53ef\u4ee5\u8986\u76d6\u6240\u6709\u7684\u7cbe\u7ec6\u5316\u5de5\u9886\u57df\u3002<\/p>\n

1.\u589e\u6eb6<\/p>\n

\u8981\u6c42\uff1aC>CMC \uff08 HLB13~18\uff09<\/p>\n

\u4e34\u754c\u80f6\u675f\u6d53\u5ea6\uff08CMC\uff09\uff1a\u8868\u9762\u6d3b\u6027\u5242\u5206\u5b50\u7f14\u5408\u5f62\u6210\u80f6\u675f\u7684\u4f4e\u6d53\u5ea6\u3002\u5f53\u5176\u6d53\u5ea6\u9ad8\u4e8eCMC\u503c\u65f6\uff0c\u8868\u9762\u6d3b\u6027\u5242\u7684\u6392\u5217\u6210\u7403\u72b6\u3001\u68d2\u72b6\u3001\u675f\u72b6\u3001\u5c42\u72b6\/\u677f\u72b6\u7b49\u7ed3\u6784\u3002<\/p>\n

\u589e\u6eb6\u4f53\u7cfb\u4e3a\u70ed\u529b\u5b66\u5e73\u8861\u4f53\u7cfb\uff1b<\/p>\n

CMC\u8d8a\u4f4e\u3001\u7f14\u5408\u6570\u8d8a\u5927\uff0c\u589e\u6eb6\u91cf\uff08MAC\uff09\u5c31\u8d8a\u9ad8\uff1b<\/p>\n

\u6e29\u5ea6\u5bf9\u589e\u6eb6\u7684\u5f71\u54cd\uff1a\u6e29\u5ea6\u5f71\u54cd\u80f6\u675f\u7684\u5f62\u6210\uff0c\u5f71\u54cd\u589e\u6eb6\u8d28\u7684\u6eb6\u89e3\uff0c\u5f71\u54cd\u8868\u9762\u6d3b\u6027\u5242\u7684\u6eb6\u89e3\u5ea6<\/p>\n

Krafft\u70b9\uff1a\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242\u7684\u6eb6\u89e3\u5ea6\u968f\u6e29\u5ea6\u589e\u52a0\u800c\u6025\u5267\u589e\u5927\u8fd9\u4e00\u6e29\u5ea6\u79f0\u4e3aKrafft\u70b9\uff0c Krafft\u70b9\u8d8a\u9ad8\uff0c\u5176\u4e34\u754c\u80f6\u675f\u6d53\u5ea6\u8d8a\u5c0f<\/p>\n

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2.\u4e73\u5316\u4f5c\u7528<\/p>\n

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\u6df7\u5408\u52a0\u548c\u6027\uff1aHLB=\uff08HLBa Wa+HLBb \/Wb)\/ (Wa+Wb)<\/p>\n

\u7406\u8bba\u8ba1\u7b97\uff1aHLB=\u2211(\u4eb2\u6c34\u57fa\u56e2HLB\u503c)+\u2211(\u4eb2\u6cb9\u57fa\u56e2HLB)-7<\/p>\n

HLB\uff1a3-8 W \/O\u578b\u4e73\u5316\u5242\uff1aSpan\uff1b\u4e8c\u4ef7\u7682<\/p>\n

HLB\uff1a8-16 O\/W\u578b\u4e73\u5316\u5242\uff1aTween\uff1b\u4e00\u4ef7\u7682<\/p>\n

3.\u6da6\u6e7f\u4f5c\u7528<\/p>\n

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4.\u52a9\u60ac\u4f5c\u7528<\/p>\n

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5.\u8d77\u6ce1\u548c\u6d88\u6ce1\u4f5c\u7528<\/p>\n

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6.\u6d88\u6bd2\u3001\u6740\u83cc<\/p>\n

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7.\u6297\u786c\u6c34\u6027<\/p>\n

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8.\u589e\u7c98\u6027\u53ca\u589e\u6ce1\u6027<\/p>\n

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9.\u53bb\u57a2\u3001\u6d17\u6da4\u4f5c\u7528<\/p>\n

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